Panax Notoginseng Saponins (PNS): Clinical Data Summary
Panax notoginseng saponins (PNS) are the primary active components extracted from the root or rhizome of Panax notoginseng (also known as Tianqi or Sanqi), containing various saponins such as ginsenosides Rg1, Rb1, Re, Rd, and notoginsenoside R1. Clinical research has primarily focused on its effects in cardiovascular and cerebrovascular diseases, anti-inflammatory activity, antioxidant properties, and tissue protection. Below is a summary of existing clinical data: Cardiovascular and Cerebrovascular Diseases (1) Ischemic Stroke Clinical Studies : Multiple randomized controlled trials (RCTs) indicate that PNS (e.g., Xuesaitong Injection or oral formulations) combined with conventional treatment (e.g., aspirin) can improve neurological deficit scores (NIHSS) and daily living ability (Barthel Index) in stroke patients, with significantly higher efficacy than control groups (PMID: 32350721). Mechanism : Inhibits platelet aggregation, improves microcircu...